JMJD6 antibody (N-Term)

Catalog No. ABIN6241759

Product Details anti-JMJD6 Antibody

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Binding Specificity: N-Term

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This JMJD6 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Immunogen: Recombinant Protein

Application Details

Application Notes: WB: 1:1000. ICC: 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for JMJD6

Target: JMJD6 (Jumonji Domain Containing 6 (JMJD6))

Alternative Name: JMJD6 (JMJD6 Products)

Background: Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.

UniProt: Q6NYC1