Cyclin H antibody

Catalog No. ABIN6241261

Product Details anti-Cyclin H Antibody

Target: Cyclin H (CCNH)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin H antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Immunogen: Recombinant Protein

Application Details

Application Notes: IP: 1:500. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C,-20 °C

Target Details for Cyclin H

Target: Cyclin H (CCNH)

Alternative Name: Cyclin H (CCNH Products)

Background: Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

UniProt: P51946

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase