DBC1 antibody
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- Target See all DBC1 (BRINP1) Antibodies
- DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))
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Reactivity
- Human, Mouse
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This DBC1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- Immunogen
- Recombinant Protein
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anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 20-320) antibody
BRINP1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 101-200) antibodyBRINP1 Reactivity: Human, Mouse, Rat WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 1-320) antibodyBRINP1 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 1-320) antibodyBRINP1 Reactivity: Human WB, IF Host: Mouse Polyclonal unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 85-111), (N-Term) antibodyBRINP1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB22619 unconjugated
anti-Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1) (AA 662-761) antibodyBRINP1 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
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- Application Notes
- IP: 1:500. WB: 1:500. ICC: 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Storage
- 4 °C,-20 °C
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- Target
- DBC1 (BRINP1) (Bone Morphogenetic Protein/retinoic Acid Inducible Neural-Specific 1 (BRINP1))
- Alternative Name
- DBC1 (BRINP1 Products)
- Synonyms
- Dbc1 antibody, Dbccr1 antibody, BRINP antibody, Fam5a antibody, BMP/retinoic acid inducible neural specific 1 antibody, bone morphogenic protein/retinoic acid inducible neural specific 1 antibody, Brinp1 antibody, BRINP1 antibody
- Background
- Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.
- UniProt
- Q8N163
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