PTEN antibody (pThr366)

Catalog No. ABIN6241051

Product Details anti-PTEN Antibody

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Binding Specificity: pThr366

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTEN antibody is un-conjugated

Application: Dot Blot (DB)

Predicted Reactivity: M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T366 of human PTEN.

Clone: RB39731

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PTEN

Target: PTEN (Phosphatase and Tensin Homolog (PTEN))

Alternative Name: PTEN (PTEN Products)

Synonyms: 10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody

Background: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.

Molecular Weight: 47166

NCBI Accession: NP_000305

UniProt: P60484

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling