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CD19 antibody (PE)

CD19 Reactivity: Mouse FACS Host: Rat Monoclonal 1D3 PE
Catalog No. ABIN616759
  • Target See all CD19 Antibodies
    CD19 (CD19 Molecule (CD19))
    Reactivity
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    Mouse
    Host
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    Rat
    Clonality
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    Monoclonal
    Conjugate
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    This CD19 antibody is conjugated to PE
    Application
    • 253
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    Flow Cytometry (FACS)
    Specificity
    This antibody detects mouse CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Immunogen
    Mouse CD19-transfected cell line
    Clone
    1D3
    Isotype
    IgG2a
    Top Product
    Discover our top product CD19 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    PBS, pH 7.4, 15 mM sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Dilute only prior to immediate use
    Storage
    4 °C
    Storage Comment
    Store the antibody (undiluted) at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
  • Target
    CD19 (CD19 Molecule (CD19))
    Alternative Name
    CD19 (CD19 Products)
    Background
    CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
    Gene ID
    12478
    NCBI Accession
    NP_033974
    UniProt
    P25918
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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