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CD19 antibody

CD19 Reactivity: Mouse FACS, IP, IHC (fro), Func Host: Rat Monoclonal 1D3 unconjugated
Catalog No. ABIN616757
  • Target See all CD19 Antibodies
    CD19 (CD19 Molecule (CD19))
    Reactivity
    • 281
    • 148
    • 41
    • 29
    • 19
    • 10
    • 7
    • 5
    • 4
    • 3
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    Mouse
    Host
    • 171
    • 130
    • 41
    • 4
    Rat
    Clonality
    • 227
    • 115
    • 2
    Monoclonal
    Conjugate
    • 122
    • 22
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    • 17
    • 8
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    • 3
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    • 2
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CD19 antibody is un-conjugated
    Application
    • 253
    • 113
    • 70
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    • 51
    • 49
    • 23
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    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)
    Specificity
    This antibody detects detects mouse CD19, 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells, it is lost on plasma cells.
    Cross-Reactivity (Details)
    Species reactivity (tested):Mouse
    Purification
    Protein-G affinity chromatography
    Endotoxin Level
    Less than 10 EU/mg of the protein, as determined by the LAL test
    Immunogen
    Mouse CD19-transfected cell line
    Clone
    1D3
    Isotype
    IgG2a
    Top Product
    Discover our top product CD19 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    Azide free PBS, pH ~7.4
    Preservative
    Azide free
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD19 (CD19 Molecule (CD19))
    Alternative Name
    CD19 (CD19 Products)
    Background
    CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.Synonyms: B-cell marker, B-lymphocyte surface antigen B4, Differentiation antigen CD19, Leu-12
    Gene ID
    12478
    NCBI Accession
    NP_033974
    UniProt
    P25918
    Pathways
    Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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