TSHR, A Chain antibody (CF®594)
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- Target See all TSHR, A Chain products
- TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
- Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TSHR, A Chain antibody is conjugated to CF®594
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Purpose
- Mouse Monoclonal anti-TSH Receptor, A chain (TSHRA/1401), CF594 Conjugate
- Characteristics
- Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- Immunogen
- A-Chain protein|Recombinant human TSHR
- Clone
- TSHRA-1401
- Isotype
- IgG1
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- Application Notes
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Immunohistology (frozen) 0.5-1 μg/mL
- Flow Cytometry 0.5-1 μg/million cells/0.1 mL
- Immunofluorescence 1-2 μg/mL
- Optimal dilution for a specific application should be determined by user
- Comment
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293T Cells. Thyroid gland
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 100 μg/mL
- Buffer
- PBS/0.1 % BSA/0.05 % azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from light
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- Target
- TSHR, A Chain (Thyroid Stimulating Hormone Receptor, A Chain (TSHR, A Chain))
- Alternative Name
- TSH Receptor, A chain (TSHR, A Chain Products)
- Background
- CHNG1, hTSHRI, LGR3, Thyroid-stimulating hormone receptor, Thyrotropin receptor, Thyrotropin receptor I, TSHR
- Molecular Weight
- 62 kDa
- Gene ID
- 7253, 160411
- UniProt
- P16473
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