ZRANB3 antibody (AA 818-1077)

Catalog No. ABIN6150540

Product Details anti-ZRANB3 Antibody

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Binding Specificity: AA 818-1077

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZRANB3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: ITKQQTKQNC TKRYITKEDV AVASMDKVKN VGGHVRLITK ESRPRDPFTK KLLEDGACVP FLNPYTVQAD LTVKPSTSKG YLQAVDNEGN PLCLRCQQPT CQTKQACKAN SWDSRFCSLK CQEEFWIRSN NSYLRAKVFE TEHGVCQLCN VNAQELFLRL RDAPKSQRKN LLYATWTSKL PLEQLNEMIR NPGEGHFWQV DHIKPVYGGG GQCSLDNLQT LCTVCHKERT ARQAKERSQV RRQSLASKHG SDITRFLVKK

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 818-1077 of human ZRANB3 (NP_001273497.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:3000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-ZRANB3 antibody (ABIN6150540)

Margalef, Kotsantis, Borel, Bellelli, Panier, Boulton: "Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe." in: Cell, Vol. 172, Issue 3, pp. 439-453.e14, (2019) (PubMed).

Target Details for ZRANB3

Target: ZRANB3 (Zinc Finger, RAN-Binding Domain Containing 3 (ZRANB3))

Alternative Name: ZRANB3 (ZRANB3 Products)

Synonyms: 4933425L19Rik antibody, AH2 antibody, AI316834 antibody, C730006D09 antibody, zinc finger RANBP2-type containing 3 antibody, zinc finger, RAN-binding domain containing 3 antibody, ZRANB3 antibody, Zranb3 antibody

Background: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.,ZRANB3,4933425L19Rik,AH2,Epigenetics & Nuclear Signaling,ZRANB3

Molecular Weight: 42 kDa/49 kDa/67 kDa/123 kDa

Gene ID: 84083

UniProt: Q5FWF4