RECQL2 antibody (AA 1223-1432)

Catalog No. ABIN6150263

Product Details anti-RECQL2 Antibody

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Binding Specificity: AA 1223-1432

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECQL2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: CQTNSVQTDL FSSTKPQEEQ KTSLVAKNKI CTLSQSMAIT YSLFQEKKMP LKSIAESRIL PLMTIGMHLS QAVKAGCPLD LERAGLTPEV QKIIADVIRN PPVNSDMSKI SLIRMLVPEN IDTYLIHMAI EILKHGPDSG LQPSCDVNKR RCFPGSEEIC SSSKRSKEEV GINTETSSAE RKRRLPVWFA KGSDTSKKLM DKTKRGGLFS

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1223-1432 of human WRN (NP_000544.2).

Isotype: IgG

Application Details

Application Notes: WB,1:200 - 1:1000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Alternative Name: WRN (WRN Products)

Background: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.,WRN,RECQ3,RECQL2,RECQL3,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cell Biology & Developmental Biology,Apoptosis,WRN

Molecular Weight: 162 kDa

Gene ID: 7486

UniProt: Q14191

Pathways: DNA Damage Repair