ube3a antibody (AA 300-590)

Catalog No. ABIN6149835

Product Details anti-ube3a Antibody

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Binding Specificity: AA 300-590

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ube3a antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: KLIRLWSKYN ADQIRRMMET FQQLITYKVI SNEFNSRNLV NDDDAIVAAS KCLKMVYYAN VVGGEVDTNH NEEDDEEPIP ESSELTLQEL LGEERRNKKG PRVDPLETEL GVKTLDCRKP LIPFEEFINE PLNEVLEMDK DYTFFKVETE NKFSFMTCPF ILNAVTKNLG LYYDNRIRMY SERRITVLYS LVQGQQLNPY LRLKVRRDHI IDDALVRLEM IAMENPADLK KQLYVEFEGE QGVDEGGVSK EFFQLVVEEI FNPDIGMFTY DESTKLFWFN PSSFETEGQF T

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human UBE3A (NP_570853.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ube3a

Target: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Alternative Name: UBE3A (ube3a Products)

Background: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.,UBE3A,ANCR,AS,E6-AP,EPVE6AP,HPVE6A,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cell Biology & Developmental Biology,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Neuroscience,Neurodegenerative Diseases,UBE3A

Molecular Weight: 97 kDa/100 kDa

Gene ID: 7337

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway