TRIB1 antibody (AA 203-372)

Catalog No. ABIN6149494

Product Details anti-TRIB1 Antibody

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Binding Specificity: AA 203-372

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIB1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LGDLKLRKFV FSTEERTQLR LESLEDTHIM KGEDDALSDK HGCPAYVSPE ILNTTGTYSG KAADVWSLGV MLYTLLVGRY PFHDSDPSAL FSKIRRGQFC IPEHISPKAR CLIRSLLRRE PSERLTAPEI LLHPWFESVL EPGYIDSEIG TSDQIVPEYQ EDSDISSFFC

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 203-372 of human TRIB1 (NP_079471.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TRIB1

Target: TRIB1 (Tribbles Homolog 1 (TRIB1))

Alternative Name: TRIB1 (TRIB1 Products)

Background: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.,TRIB1,C8FW,GIG-2,GIG2,SKIP1,TRB-1,TRB1,Signal Transduction,Kinase,Endocrine & Metabolism,Stem Cells,Hematopoietic Progenitors,Cardiovascular,TRIB1

Molecular Weight: 23 kDa/41 kDa

Gene ID: 10221

UniProt: Q96RU8

Pathways: Smooth Muscle Cell Migration