TOPBP1 antibody (AA 1253-1522)

Catalog No. ABIN6149398

Product Details anti-TOPBP1 Antibody

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Binding Specificity: AA 1253-1522

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOPBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: KIITIEETHE ELKKQYIFQL SSLNPQERID YCHLIEKLGG LVIEKQCFDP TCTHIVVGHP LRNEKYLASV AAGKWVLHRS YLEACRTAGH FVQEEDYEWG SSSILDVLTG INVQQRRLAL AAMRWRKKIQ QRQESGIVEG AFSGWKVILH VDQSREAGFK RLLQSGGAKV LPGHSVPLFK EATHLFSDLN KLKPDDSGVN IAEAAAQNVY CLRTEYIADY LMQESPPHVE NYCLPEAISF IQNNKELGTG LSQKRKAPTE KNKIKRPRVH

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1253-1522 of human TOPBP1 (NP_008958.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-TOPBP1 antibody (ABIN6149398)

Wang, Wang, Xin, Wang, Wang, Xu, Jia, Yue, Wang, Song: "Two novel LRR-only proteins in Chlamys farreri: Similar in structure, yet different in expression profile and pattern recognition." in: Developmental and comparative immunology, Vol. 59, pp. 99-109, (2017) (PubMed).

Target Details for TOPBP1

Target: TOPBP1 (Topoisomerase (DNA) II Binding Protein 1 (TOPBP1))

Alternative Name: TOPBP1 (TOPBP1 Products)

Background: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands.,TOPBP1,TOP2BP1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,Cancer,Drug resistance,Topoisomerases,TOPBP1

Molecular Weight: 170 kDa

Gene ID: 11073

UniProt: Q92547

Pathways: Chromatin Binding