TOP3B antibody (AA 1-270)

Catalog No. ABIN6149394

Product Details anti-TOP3B Antibody

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Binding Specificity: AA 1-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOP3B antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MKTVLMVAEK PSLAQSIAKI LSRGSLSSHK GLNGACSVHE YTGTFAGQPV RFKMTSVCGH VMTLDFLGKY NKWDKVDPAE LFSQAPTEKK EANPKLNMVK FLQVEGRGCD YIVLWLDCDK EGENICFEVL DAVLPVMNKA HGGEKTVFRA RFSSITDTDI CNAMACLGEP DHNEALSVDA RQELDLRIGC AFTRFQTKYF QGKYGDLDSS LISFGPCQTP TLGFCVERHD KIQSFKPETY WVLQAKVNTD KDRSLLLDWD RVRVFDREIA

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human TOP3B (NP_003926.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TOP3B

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Alternative Name: TOP3B (TOP3B Products)

Synonyms: TOP3B1 antibody, top3b antibody, DNA topoisomerase III beta antibody, topoisomerase (DNA) III beta antibody, DNA topoisomerase III beta L homeolog antibody, TOP3B antibody, Top3b antibody, top3b.L antibody

Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.,TOP3B,TOP3B1,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Drug resistance,Topoisomerases,TOP3B

Molecular Weight: 79 kDa/82 kDa/96 kDa

Gene ID: 8940

UniProt: O95985