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THO Complex 5 antibody (AA 150-370)

THOC5 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6149119
  • Target See all THO Complex 5 (THOC5) Antibodies
    THO Complex 5 (THOC5)
    Binding Specificity
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 150-370
    Reactivity
    • 26
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 1
    Rabbit
    Clonality
    • 26
    Polyclonal
    Conjugate
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This THO Complex 5 antibody is un-conjugated
    Application
    • 13
    • 10
    • 8
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    FKSKHEEIDL VSLEEFYKEA PPDISKAEVT MGDPHQQTLA RLDWELEQRK RLAEKYRECL SNKEKILKEI EVKKEYLSSL QPRLNSIMQA SLPVQEYLFM PFDQAHKQYE TARHLPPPLY VLFVQATAYG QACDKTLSVA IEGSVDEAKA LFKPPEDSQD DESDSDAEEE QTTKRRRPTL GVQLDDKRKE MLKRHPLSVM LDLKCKDDSV LHLTFYYLMN L
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 150-370 of human THOC5 (NP_003669.4).
    Isotype
    IgG
    Top Product
    Discover our top product THOC5 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    THO Complex 5 (THOC5)
    Alternative Name
    THOC5 (THOC5 Products)
    Synonyms
    C22orf19 antibody, Fmip antibody, PK1.3 antibody, fSAP79 antibody, 1700060C24Rik antibody, A430085L24Rik antibody, Sgk2 antibody, fc54b09 antibody, wu:fc54b09 antibody, zgc:56190 antibody, zgc:76912 antibody, THOC5 antibody, fmip antibody, thoc5 antibody, thoc5-a antibody, thoc5-b antibody, THO complex 5 antibody, THO complex 5 S homeolog antibody, THO complex 5 L homeolog antibody, THOC5 antibody, Thoc5 antibody, thoc5 antibody, thoc5.S antibody, thoc5.L antibody
    Background
    Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes., Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.,THOC5,C22orf19,Fmip,PK1.3,fSAP79,Immunology & Inflammation,Cell Intrinsic Innate Immunity Signaling Pathway,THOC5
    Molecular Weight
    78 kDa
    Gene ID
    8563
    UniProt
    Q13769
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