Nesprin3 antibody (AA 740-920)

Catalog No. ABIN6148766

Product Details anti-Nesprin3 Antibody

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Binding Specificity: AA 740-920

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nesprin3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LRLLEESLLS LIRNWHLQRM EVDSGKKMVF TNNIPKSGFL INPMDPIPRH RRRANLLQEE EGSHEDFSQL LRNFGQWLQV ENSKLVRIIA MRTSTAEDLR TRKSKLQELE ARVPEGQHLF ENLLRLGPAR GTSDELEDLR YQWMLYKSKL KDSGHLLTQS SPGEPTGFQK TRRWRGLGSL F

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 740-920 of human SYNE3 (NP_689805.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Nesprin3

Target: Nesprin3 (C14orf49) (Chromosome 14 Open Reading Frame 49 (C14orf49))

Alternative Name: SYNE3 (C14orf49 Products)

Synonyms: C14orf49 antibody, NET53 antibody, Nesp3 antibody, 4831426I19Rik antibody, nesprin-3 antibody, spectrin repeat containing nuclear envelope family member 3 antibody, spectrin repeat containing, nuclear envelope family member 3 antibody, SYNE3 antibody, Syne3 antibody

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.,SYNE3,C14orf139,C14orf49,KASH3,LINC00341,NCRNA00341,NET53,Nesp3,nesprin-3,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,SYNE3

Molecular Weight: 68 kDa/111 kDa/112 kDa

Gene ID: 161176

UniProt: Q6ZMZ3

Pathways: Maintenance of Protein Location