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SUV39H2 antibody (AA 141-350)

SUV39H2 Reactivity: Human WB, ChIP, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6148749
  • Target See all SUV39H2 Antibodies
    SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
    Binding Specificity
    • 13
    • 10
    • 8
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 141-350
    Reactivity
    • 66
    • 29
    • 22
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 64
    • 2
    • 1
    Rabbit
    Clonality
    • 59
    • 8
    Polyclonal
    Conjugate
    • 33
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This SUV39H2 antibody is un-conjugated
    Application
    • 51
    • 38
    • 21
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF)
    Sequence
    CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 141-350 of human SUV39H2 (NP_001180354.1).
    Isotype
    IgG
    Top Product
    Discover our top product SUV39H2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200,ChIP,1:20 - 1:100
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
    Alternative Name
    SUV39H2 (SUV39H2 Products)
    Synonyms
    KMT1B antibody, 4930507K23Rik antibody, AA536750 antibody, D030054H19Rik antibody, D2Ertd544e antibody, SUV39H2 antibody, kmt1b antibody, suppressor of variegation 3-9 homolog 2 antibody, suppressor of variegation 3-9 homolog 2 (Drosophila) antibody, suppressor of variegation 3-9 homolog 2 L homeolog antibody, SUV39H2 antibody, Suv39h2 antibody, suv39h2 antibody, suv39h2.L antibody
    Background
    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5 proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.,SUV39H2,KMT1B,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,Chromatin Remodeling,Cell Biology & Developmental Biology,Apoptosis,SUV39H2
    Molecular Weight
    26 kDa/39 kDa/46 kDa
    Gene ID
    79723
    UniProt
    Q9H5I1
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