SUV39H2 antibody (AA 141-350)
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- Target See all SUV39H2 Antibodies
- SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
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Binding Specificity
- AA 141-350
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SUV39H2 antibody is un-conjugated
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Application
- Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunofluorescence (IF)
- Sequence
- CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 141-350 of human SUV39H2 (NP_001180354.1).
- Isotype
- IgG
- Top Product
- Discover our top product SUV39H2 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000,IF,1:50 - 1:200,ChIP,1:20 - 1:100
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))
- Alternative Name
- SUV39H2 (SUV39H2 Products)
- Synonyms
- KMT1B antibody, 4930507K23Rik antibody, AA536750 antibody, D030054H19Rik antibody, D2Ertd544e antibody, SUV39H2 antibody, kmt1b antibody, suppressor of variegation 3-9 homolog 2 antibody, suppressor of variegation 3-9 homolog 2 (Drosophila) antibody, suppressor of variegation 3-9 homolog 2 L homeolog antibody, SUV39H2 antibody, Suv39h2 antibody, suv39h2 antibody, suv39h2.L antibody
- Background
- Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5 proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.,SUV39H2,KMT1B,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,Chromatin Remodeling,Cell Biology & Developmental Biology,Apoptosis,SUV39H2
- Molecular Weight
- 26 kDa/39 kDa/46 kDa
- Gene ID
- 79723
- UniProt
- Q9H5I1
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