SUV39H1 antibody (AA 1-220)

Catalog No. ABIN6148747

Product Details anti-SUV39H1 Antibody

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Binding Specificity: AA 1-220

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)

Sequence: MAENLKGCSV CCKSSWNQLQ DLCRLAKLSC PALGISKRNL YDFEVEYLCD YKKIREQEYY LVKWRGYPDS ESTWEPRQNL KCVRILKQFH KDLERELLRR HHRSKTPRHL DPSLANYLVQ KAKQRRALRR WEQELNAKRS HLGRITVENE VDLDGPPRAF VYINEYRVGE GITLNQVAVG CECQDCLWAP TGGCCPGASL HKFAYNDQGQ VRLRAGLPIY

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SUV39H1 (NP_003164.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,ChIP,1:20 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SUV39H1 antibody (ABIN6148747)

Zhao, Lei, Zhang, Zheng, Wang, Zhao, Li, Ye, Li, Wei, Wu: "Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model." in: Clinical epigenetics, Vol. 8, pp. 34, (2016) (PubMed).

Target Details for SUV39H1

Target: SUV39H1 (Suppressor of Variegation 3-9 Homolog 1 (Drosophila) (SUV39H1))

Alternative Name: SUV39H1 (SUV39H1 Products)

Background: This gene encodes an evolutionarily-conserved protein containing an N-terminal chromodomain and a C-terminal SET domain. The encoded protein is a histone methyltransferase that trimethylates lysine 9 of histone H3, which results in transcriptional gene silencing. Loss of function of this gene disrupts heterochromatin formation and may cause chromosome instability. Alternative splicing results in multiple transcript variants.,SUV39H1,H3-K9-HMTase 1,KMT1A,MG44,SUV39H,H3-K9-HMTase1,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,Cancer,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,G1/S Checkpoint,SUV39H1

Molecular Weight: 47 kDa/49 kDa

Gene ID: 6839

UniProt: O43463