STRA13 antibody (AA 1-63)
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- Target See all STRA13 Antibodies
- STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
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Binding Specificity
- AA 1-63
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This STRA13 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MEGAGAGSGF RKELVSRLLH LHFKDDKTKE AAVRGVRQAQ AEDALRVDVD QLEKVLPQLL LDF
- Cross-Reactivity
- Human
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human STRA13 (NP_659435.2).
- Isotype
- IgG
- Top Product
- Discover our top product STRA13 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
- Alternative Name
- STRA13 (STRA13 Products)
- Synonyms
- CENP-X antibody, CENPX antibody, D9 antibody, FAAP10 antibody, MHF2 antibody, BHLHB2 antibody, centromere protein X antibody, CENPX antibody, Cenpx antibody
- Background
- DNA-binding component of the Fanconi anemia (FA core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer, crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins, rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer, involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.,CENPX,CENP-X,D9,FAAP10,MHF2,STRA13,Epigenetics & Nuclear Signaling,DNA Damage & Repair,STRA13
- Molecular Weight
- 6 kDa/7 kDa/8 kDa
- Gene ID
- 201254
- UniProt
- A8MT69
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