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STRA13 antibody (AA 1-63)

STRA13 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6148631
  • Target See all STRA13 Antibodies
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Binding Specificity
    • 4
    • 1
    AA 1-63
    Reactivity
    Human
    Host
    • 6
    Rabbit
    Clonality
    • 6
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    This STRA13 antibody is un-conjugated
    Application
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    MEGAGAGSGF RKELVSRLLH LHFKDDKTKE AAVRGVRQAQ AEDALRVDVD QLEKVLPQLL LDF
    Cross-Reactivity
    Human
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human STRA13 (NP_659435.2).
    Isotype
    IgG
    Top Product
    Discover our top product STRA13 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    Alternative Name
    STRA13 (STRA13 Products)
    Synonyms
    CENP-X antibody, CENPX antibody, D9 antibody, FAAP10 antibody, MHF2 antibody, BHLHB2 antibody, centromere protein X antibody, CENPX antibody, Cenpx antibody
    Background
    DNA-binding component of the Fanconi anemia (FA core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer, crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins, rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer, involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own.,CENPX,CENP-X,D9,FAAP10,MHF2,STRA13,Epigenetics & Nuclear Signaling,DNA Damage & Repair,STRA13
    Molecular Weight
    6 kDa/7 kDa/8 kDa
    Gene ID
    201254
    UniProt
    A8MT69
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