STK4 antibody (AA 303-487)

Catalog No. ABIN6148620

Product Details anti-STK4 Antibody

Target: STK4 (serine/threonine Kinase 4 (STK4))

Binding Specificity: AA 303-487

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Sequence: KRQESQQREV DQDDEENSEE DEMDSGTMVR AVGDEMGTVR VASTMTDGAN TMIEHDDTLP SQLGTMVINA EDEEEEGTMK RRDETMQPAK PSFLEYFEQK EKENQINSFG KSVPGPLKNS SDWKIPQDGD YEFLKSWTVE DLQKRLLALD PMMEQEIEEI RQKYQSKRQP ILDAIEAKKR RQQNF

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 303-487 of human MST1/STK4 (NP_006273.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-STK4 antibody (ABIN6148620)

Zhang, Xu, Xu, Wei, Xu: "Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition." in: Human reproduction (Oxford, England), Vol. 31, Issue 4, pp. 832-43, (2016) (PubMed).

Target Details for STK4

Target: STK4 (serine/threonine Kinase 4 (STK4))

Alternative Name: STK4 (STK4 Products)

Background: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.,KRS2,MST1,YSK3,STK4,Signal Transduction,Kinase,Serine/threonine kinases,Cell Biology & Developmental Biology,Apoptosis,Autophagy,Hippo Signaling Pathway,Cardiovascular,Heart,Hypertrophy,STK4

Molecular Weight: 52 kDa/55 kDa

Gene ID: 6789

UniProt: Q13043

Pathways: Tube Formation