SPTA1 antibody (AA 940-1160)

Catalog No. ABIN6148401

Product Details anti-SPTA1 Antibody

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Binding Specificity: AA 940-1160

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: KHEAFLLDLN SFGDSMKALR NQANACQQQQ AAPVEGVAGE QRVMALYDFQ ARSPREVTMK KGDVLTLLSS INKDWWKVEA ADHQGIVPAV YVRRLAHDEF PMLPQRRREE PGNITQRQEQ IENQYRSLLD RAEERRRRLL QRYNEFLLAY EAGDMLEWIQ EKKAENTGVE LDDVWELQKK FDEFQKDLNT NEPRLRDINK VADDLLFEGL LTPEGAQIRQ E

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 940-1160 of human alpha 1 Spectrin (NP_003117.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SPTA1 antibody (ABIN6148401)

Talhouarne, Gall: "7SL RNA in vertebrate red blood cells." in: RNA (New York, N.Y.), Vol. 24, Issue 7, pp. 908-914, (2018) (PubMed).

Target Details for SPTA1

Target: SPTA1 (Spectrin alpha 1, Erythrocytic (SPTA1))

Alternative Name: SPTA1 (SPTA1 Products)

Synonyms: Spna1 antibody, AF093576 antibody, AI451697 antibody, Spna-1 antibody, ha antibody, ihj antibody, nmf4 antibody, sph antibody, EL2 antibody, HPP antibody, HS3 antibody, SPH3 antibody, SPTA antibody, spectrin, alpha, erythrocytic 1 antibody, spectrin alpha, erythrocytic 1 antibody, Spta1 antibody, SPTA1 antibody

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.,SPTA1,EL2,HPP,HS3,SPH3,SPTA,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Microfilaments,Cardiovascular,Blood,Blood Cell Antigens,SPTA1

Molecular Weight: 279 kDa/280 kDa

Gene ID: 6708

UniProt: P02549

Pathways: Regulation of Actin Filament Polymerization