Sortilin 1 antibody (AA 520-760)

Catalog No. ABIN6148281

Product Details anti-Sortilin 1 Antibody

Target: Sortilin 1 (SORT1)

Binding Specificity: AA 520-760

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Sortilin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EGPHYYTILD SGGIIVAIEH SSRPINVIKF STDEGQCWQT YTFTRDPIYF TGLASEPGAR SMNISIWGFT ESFLTSQWVS YTIDFKDILE RNCEEKDYTI WLAHSTDPED YEDGCILGYK EQFLRLRKSS VCQNGRDYVV TKQPSICLCS LEDFLCDFGY YRPENDSKCV EQPELKGHDL EFCLYGREEH LTTNGYRKIP GDKCQGGVNP VREVKDLKKK CTSNFLSPEK QNSKSNSVPI I

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 520-760 of human SORT1 (NP_002950.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Sortilin 1

Target: Sortilin 1 (SORT1)

Alternative Name: SORT1 (SORT1 Products)

Background: This gene encodes a member of the VPS10-related sortilin family of proteins. The encoded preproprotein is proteolytically processed by furin to generate the mature receptor. This receptor plays a role in the trafficking of different proteins to either the cell surface, or subcellular compartments such as lysosomes and endosomes. Expression levels of this gene may influence the risk of myocardial infarction in human patients. Alternative splicing results in multiple transcript variants.,SORT1,Gp95,LDLCQ6,NT3,NTR3,sortilin,Cancer,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Lipid Metabolism,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Cardiovascular,Heart,Lipids,Lipoproteins/Apolipoproteins,Cardiovascular diseases,Heart disease,SORT1

Molecular Weight: 77 kDa/92 kDa

Gene ID: 6272

UniProt: Q99523

Pathways: Neurotrophin Signaling Pathway