SOCS6 antibody (AA 1-210)

Catalog No. ABIN6148273

Product Details anti-SOCS6 Antibody

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Binding Specificity: AA 1-210

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS ETTCQEQANS LKSSASHNGD LHLHLDEHVP

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_004223.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SOCS6

Target: SOCS6 (Suppressor of Cytokine Signaling 6 (SOCS6))

Alternative Name: SOCS6 (SOCS6 Products)

Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.,SOCS6,CIS-4,CIS4,HSPC060,SOCS-4,SOCS-6,SOCS4,SSI4,STAI4,STATI4,Epigenetics & Nuclear Signaling,Signal Transduction,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,SOCS6

Molecular Weight: 59 kDa

Gene ID: 9306

UniProt: O14544

Pathways: JAK-STAT Signaling, Carbohydrate Homeostasis