SOAT1 antibody (AA 1-130)

Catalog No. ABIN6148259

Product Details anti-SOAT1 Antibody

Target: SOAT1 (Sterol O-Acyltransferase 1 (SOAT1))

Binding Specificity: AA 1-130

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOAT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: MVGEEKMSLR NRLSKSRENP EEDEDQRNPA KESLETPSNG RIDIKQLIAK KIKLTAEAEE LKPFFMKEVG SHFDDFVTNL IEKSASLDNG GCALTTFSVL EGEKNNHRAK DLRAPPEQGK IFIARRSLLD

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SOAT1 (NP_003092.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SOAT1 antibody (ABIN6148259)

Hai, Ritchey, Robinet, Alzayed, Brubaker, Zhang, Smith: "Quantitative Trait Locus Mapping of Macrophage Cholesterol Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as a Causal Modifier Variant." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 38, Issue 1, pp. 83-91, (2019) (PubMed).

Target Details for SOAT1

Target: SOAT1 (Sterol O-Acyltransferase 1 (SOAT1))

Alternative Name: SOAT1 (SOAT1 Products)

Background: The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.,SOAT1,ACACT,ACAT,ACAT-1,ACAT1,SOAT,STAT,Cancer,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Heart,Lipids,Lipoproteins/Apolipoproteins,Cardiovascular diseases,Heart disease,SOAT1

Molecular Weight: 57 kDa/58 kDa/64 kDa

Gene ID: 6646

UniProt: P35610