RGD1560190 antibody, SLAMF7 antibody, slaf7 antibody, 19A antibody, CD319 antibody, CRACC antibody, CS1 antibody, 19A24 antibody, 4930560D03Rik antibody, SLAM family member 7 antibody, Slamf7 antibody, SLAMF7 antibody, slaf7 antibody
Background
SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed on the surface of NK cells, CD8+ T cells, activated B cells, and mature dendritic cells but not in promyelocytic, B-cell lines, or T-cell lines. In human NK cells, activated SLAMF7 transmits signals following association with the adaptor protein EAT-2 . In the absence of EAT-2, SLAMF7 potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.,SLAMF7,19A,CD319,CRACC,CS1,Cell Biology & Developmental Biology,Apoptosis,Immunology & Inflammation,CD markers,SLAMF7