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RPE65 antibody (AA 274-533)

RPE65 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6147090
  • Target See all RPE65 Antibodies
    RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
    Binding Specificity
    • 6
    • 1
    • 1
    AA 274-533
    Reactivity
    • 39
    • 31
    • 31
    • 10
    • 2
    • 1
    • 1
    Human
    Host
    • 38
    • 7
    • 1
    Rabbit
    Clonality
    • 29
    • 17
    Polyclonal
    Conjugate
    • 15
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RPE65 antibody is un-conjugated
    Application
    • 34
    • 14
    • 13
    • 9
    • 7
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    NYMDCFESNE TMGVWLHIAD KKRKKYLNNK YRTSPFNLFH HINTYEDNGF LIVDLCCWKG FEFVYNYLYL ANLRENWEEV KKNARKAPQP EVRRYVLPLN IDKADTGKNL VTLPNTTATA ILCSDETIWL EPEVLFSGPR QAFEFPQINY QKYCGKPYTY AYGLGLNHFV PDRLCKLNVK TKETWVWQEP DSYPSEPIFV SHPDALEEDD GVVLSVVVSP GAGQKPAYLL ILNAKDLSEV ARAEVEINIP VTFHGLFKKS
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1).
    Isotype
    IgG
    Top Product
    Discover our top product RPE65 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))
    Alternative Name
    RPE65 (RPE65 Products)
    Synonyms
    LCA2 antibody, RP20 antibody, mRPE65 antibody, rd12 antibody, sRPE65 antibody, 65kDa antibody, A930029L06Rik antibody, Mord1 antibody, DRPE65 antibody, RPE65 antibody, anon-WO0148162.1 antibody, anon-WO0148163.1 antibody, beta-diox antibody, DmelCG9347 antibody, CG9347 antibody, MGC52887 antibody, MGC154296 antibody, MGC85437 antibody, rpe65 antibody, RPE56c antibody, si:ch211-198n5.12 antibody, 13cIMH antibody, RPE56b antibody, rpepb antibody, si:ch211-198n5.5 antibody, wu:fc74c09 antibody, zgc:110538 antibody, RPE56a antibody, rpepa antibody, zgc:73213 antibody, RPE65, retinoid isomerohydrolase antibody, retinal pigment epithelium 65 antibody, neither inactivation nor afterpotential B antibody, retinal pigment epithelium-specific protein 65kDa S homeolog antibody, retinal pigment epithelium-specific protein 65kDa L homeolog antibody, RPE65 homolog antibody, retinal pigment epithelium-specific protein 65kDa antibody, retinal pigment epithelium-specific protein 65c antibody, retinal pigment epithelium-specific protein 65b antibody, retinal pigment epithelium-specific protein 65a antibody, RPE65 antibody, Rpe65 antibody, ninaB antibody, rpe65.S antibody, rpe65.L antibody, rpe65 antibody, rpe65c antibody, rpe65b antibody, rpe65a antibody
    Background
    This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.,RPE65,BCO3,LCA2,RP20,mRPE65,rd12,sRPE65,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Cell Type Marker,RPE65
    Molecular Weight
    60 kDa
    Gene ID
    6121
    UniProt
    Q16518
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