RPE65 antibody (AA 274-533)

Catalog No. ABIN6147090

Product Details anti-RPE65 Antibody

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Binding Specificity: AA 274-533

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPE65 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: NYMDCFESNE TMGVWLHIAD KKRKKYLNNK YRTSPFNLFH HINTYEDNGF LIVDLCCWKG FEFVYNYLYL ANLRENWEEV KKNARKAPQP EVRRYVLPLN IDKADTGKNL VTLPNTTATA ILCSDETIWL EPEVLFSGPR QAFEFPQINY QKYCGKPYTY AYGLGLNHFV PDRLCKLNVK TKETWVWQEP DSYPSEPIFV SHPDALEEDD GVVLSVVVSP GAGQKPAYLL ILNAKDLSEV ARAEVEINIP VTFHGLFKKS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 274-533 of human RPE65 (NP_000320.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RPE65

Target: RPE65 (Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65))

Alternative Name: RPE65 (RPE65 Products)

Background: This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.,RPE65,BCO3,LCA2,RP20,mRPE65,rd12,sRPE65,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Cell Type Marker,RPE65

Molecular Weight: 60 kDa

Gene ID: 6121

UniProt: Q16518