RNF166 antibody (C-Term)

Catalog No. ABIN6147021

Product Details anti-RNF166 Antibody

Target: RNF166 (Ring Finger Protein 166 (RNF166))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF166 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: GCNKKVTLAK MRVHISSCLK VQEQMANCPK FVPVVPTSQP IPSNIPNRST FACPYCGARN LDQQELVKHC VESHRSDPNR VVCPICSAMP WGDPSYKSAN FLQHLLHRHK FSYDTFVDYS IDEEAAFQAA LALSLSEN

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RNF166 (NP_849163.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-RNF166 antibody (ABIN6147021)

Lu, Chen, Tung, Chen, Pan, Chang, Cheng, Chen, Wang, Huang, Kang, Chang, Li, Chang, Shih, Lin, Kwan, Tsai: "Identification of genes associated with cortical malformation using a transposon-mediated somatic mutagenesis screen in mice." in: Nature communications, Vol. 9, Issue 1, pp. 2498, (2019) (PubMed).

Target Details for RNF166

Target: RNF166 (Ring Finger Protein 166 (RNF166))

Alternative Name: RNF166 (RNF166 Products)

Synonyms: 1110031E24Rik antibody, AW555115 antibody, Zfp313l antibody, ring finger protein 166 antibody, ring finger protein 166 L homeolog antibody, RNF166 antibody, rnf166.L antibody, Rnf166 antibody

Background: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates. In turn, participates in different biological processes including interferon production or autophagy. Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6. Plays also a role in the early recruitment of autophagy adapters to bacteria. Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication.,RNF166,Cell Biology & Developmental Biology,Ubiquitin,RNF166

Molecular Weight: 14 kDa/17 kDa/26 kDa

Gene ID: 115992

UniProt: Q96A37