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RAG2 antibody (AA 258-527)

RAG2 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6146663
  • Target See all RAG2 Antibodies
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Binding Specificity
    • 15
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 258-527
    Reactivity
    • 44
    • 13
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 39
    • 6
    Rabbit
    Clonality
    • 41
    • 4
    Polyclonal
    Conjugate
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RAG2 antibody is un-conjugated
    Application
    • 19
    • 13
    • 13
    • 12
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    VSSAILTQTN NDEFVIVGGY QLENQKRMIC NIISLEDNKI EIREMETPDW TPDIKHSKIW FGSNMGNGTV FLGIPGDNKQ VVSEGFYFYM LKCAEDDTNE EQTTFTNSQT STEDPGDSTP FEDSEEFCFS AEANSFDGDD EFDTYNEDDE EDESETGYWI TCCPTCDVDI NTWVPFYSTE LNKPAMIYCS HGDGHWVHAQ CMDLAERTLI HLSAGSNKYY CNEHVEIARA LHTPQRVLPL KKPPMKSLRK KGSGKILTPA KKSFLRRLFD
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human RAG2 (NP_001230715.1).
    Isotype
    IgG
    Top Product
    Discover our top product RAG2 Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    RAG2 (Recombination Activating Gene 2 (RAG2))
    Alternative Name
    RAG2 (RAG2 Products)
    Synonyms
    RAG-2 antibody, Rag-2 antibody, rag-2 antibody, zgc:136743 antibody, recombination activating 2 antibody, recombination activating gene 2 antibody, recombination activating gene 2 S homeolog antibody, RAG2 antibody, Rag2 antibody, rag2 antibody, rag2.S antibody
    Background
    This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.,RAG2,RAG-2,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RAG2
    Molecular Weight
    59 kDa
    Gene ID
    5897
    UniProt
    P55895
    Pathways
    Chromatin Binding, Production of Molecular Mediator of Immune Response
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