PLSCR3 antibody (AA 1-295)

Catalog No. ABIN6145798

Product Details anti-PLSCR3 Antibody

Target: PLSCR3 (phospholipid Scramblase 3 (PLSCR3))

Binding Specificity: AA 1-295

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLSCR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: MAGYLPPKGY APSPPPPYPV TPGYPEPALH PGPGQAPVPA QVPAPAPGFA LFPSPGPVAL GSAAPFLPLP GVPSGLEFLV QIDQILIHQK AERVETFLGW ETCNRYELRS GAGQPLGQAA EESNCCARLC CGARRPLRVR LADPGDREVL RLLRPLHCGC SCCPCGLQEM EVQAPPGTTI GHVLQTWHPF LPKFSIQDAD RQTVLRVVGP CWTCGCGTDT NFEVKTRDES RSVGRISKQW GGLVREALTD ADDFGLQFPL DLDVRVKAVL LGATFLIDYM FFEKRGGAGP SAVTS

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human PLSCR3 (NP_065093.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PLSCR3

Target: PLSCR3 (phospholipid Scramblase 3 (PLSCR3))

Alternative Name: PLSCR3 (PLSCR3 Products)

Synonyms: 2210403O21Rik antibody, 2610037N06Rik antibody, ESTM3 antibody, X83310 antibody, Pls3 antibody, zgc:77051 antibody, phospholipid scramblase 3 antibody, phospholipid scramblase 3b antibody, PLSCR3 antibody, Plscr3 antibody, plscr3b antibody

Background: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis.,PLSCR3,Signal Transduction,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Cardiovascular,Blood,Coagulation,PLSCR3

Molecular Weight: 31 kDa

Gene ID: 57048

UniProt: Q9NRY6

Pathways: Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis