PICALM antibody (AA 290-460)

Catalog No. ABIN6145606

Product Details anti-PICALM Antibody

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Binding Specificity: AA 290-460

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PICALM antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: IKDSTAASRA TTLSNAVSSL ASTGLSLTKV DEREKQAALE EEQARLKALK EQRLKELAKK PHTSLTTAAS PVSTSAGGIM TAPAIDIFST PSSSNSTSKL PNDLLDLQQP TFHPSVHPMS TASQVASTWG GFTPSPVAQP HPSAGLNVDF ESVFGNKSTN VIVDSGGFDE L

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 290-460 of human PICALM (NP_001008660.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PICALM

Target: PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))

Alternative Name: PICALM (PICALM Products)

Synonyms: LAP-3 antibody, PEPS antibody, CALM antibody, CLTH antibody, LAP antibody, PAP180 antibody, fit-1 antibody, fit1 antibody, mKIAA4114 antibody, Calm antibody, leucine aminopeptidase 3 antibody, phosphatidylinositol binding clathrin assembly protein antibody, si:ch211-200p22.4 antibody, LAP3 antibody, PICALM antibody, Picalm antibody, si:ch211-200p22.4 antibody

Background: This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.,PICALM,CALM,CLTH,LAP,Signal Transduction,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,PICALM

Molecular Weight: 59 kDa/66 kDa/68 kDa/70 kDa

Gene ID: 8301

UniProt: Q13492

Pathways: Synaptic Membrane