PDK4 antibody (AA 102-411)

Catalog No. ABIN6145396

Product Details anti-PDK4 Antibody

Target: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Binding Specificity: AA 102-411

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDK4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: FHEKSPDDQK ALSDFVDTLI KVRNRHHNVV PTMAQGIIEY KDACTVDPVT NQNLQYFLDR FYMNRISTRM LMNQHILIFS DSQTGNPSHI GSIDPNCDVV AVVQDAFECS RMLCDQYYLS SPELKLTQVN GKFPDQPIHI VYVPSHLHHM LFELFKNAMR ATVEHQENQP SLTPIEVIVV LGKEDLTIKI SDRGGGVPLR IIDRLFSYTY STAPTPVMDN SRNAPLAGFG YGLPISRLYA KYFQGDLNLY SLSGYGTDAI IYLKALSSES IEKLPVFNKS AFKHYQMSSE ADDWCIPSRE PKNLAKEVAM

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 102-411 of human PDK4 (NP_002603.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PDK4

Target: PDK4 (Pyruvate Dehydrogenase Kinase, Isozyme 4 (PDK4))

Alternative Name: PDK4 (PDK4 Products)

Synonyms: AV005916 antibody, pyruvate dehydrogenase kinase 4 antibody, pyruvate dehydrogenase kinase, isoenzyme 4 antibody, pdk4 antibody, PDK4 antibody, Pdk4 antibody

Background: This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.,PDK4,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Warburg Effect,PDK4

Molecular Weight: 46 kDa

Gene ID: 5166

UniProt: Q16654

Pathways: PI3K-Akt Signaling, Hedgehog Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect