PAICS antibody (AA 176-425)

Catalog No. ABIN6145178

Product Details anti-PAICS Antibody

Target: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Binding Specificity: AA 176-425

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAICS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: LEKSWLPQNC TLVDMKIEFG VDVTTKEIVL ADVIDNDSWR LWPSGDRSQQ KDKQSYRDLK EVTPEGLQMV KKNFEWVAER VELLLKSESQ CRVVVLMGST SDLGHCEKIK KACGNFGIPC ELRVTSAHKG PDETLRIKAE YEGDGIPTVF VAVAGRSNGL GPVMSGNTAY PVISCPPLTP DWGVQDVWSS LRLPSGLGCS TVLSPEGSAQ FAAQIFGLSN HLVWSKLRAS ILNTWISLKQ ADKKIRECNL

Cross-Reactivity: Human, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 176-425 of human PAICS (NP_001072992.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:10 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PAICS

Target: PAICS (phosphoribosylaminoimidazole Carboxylase, phosphoribosylaminoimidazole Succinocarboxamide Synthetase (PAICS))

Alternative Name: PAICS (PAICS Products)

Background: This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.,PAICS,ADE2,ADE2H1,AIRC,PAIS,Epigenetics & Nuclear Signaling,Signal Transduction,Endocrine & Metabolism,Nucleotide metabolism,PAICS

Molecular Weight: 47 kDa

Gene ID: 10606

UniProt: P22234

Pathways: Chromatin Binding