alpha KGDHC antibody (AA 148-427)

Catalog No. ABIN6145003

Product Details anti-alpha KGDHC Antibody

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Binding Specificity: AA 148-427

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This alpha KGDHC antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: DPLGILDADL DSSVPADIIS STDKLGFYGL DESDLDKVFH LPTTTFIGGQ ESALPLREII RRLEMAYCQH IGVEFMFIND LEQCQWIRQK FETPGIMQFT NEEKRTLLAR LVRSTRFEEF LQRKWSSEKR FGLEGCEVLI PALKTIIDKS SENGVDYVIM GMPHRGRLNV LANVIRKELE QIFCQFDSKL EAADEGSGDV KYHLGMYHRR INRVTDRNIT LSLVANPSHL EAADPVVMGK TKAEQFYCGD TEGKKVRPRE RRARQIVKAP CSSMEFRSPT

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human OGDH (NP_001003941.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:10 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-alpha KGDHC antibody (ABIN6145003)

Stein, Jadiya, Zhang, McLendon, Abouassaly, Witmer, Anderson, Elrod, Boudreau: "Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency." in: Cell reports, Vol. 23, Issue 13, pp. 3710-3720.e8, (2018) (PubMed).

Target Details for alpha KGDHC

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Alternative Name: OGDH (alphaKGDHC Products)

Synonyms: AKGDH antibody, E1k antibody, OGDC antibody, 2210403E04Rik antibody, 2210412K19Rik antibody, AA409584 antibody, d1401 antibody, mKIAA4192 antibody, oxoglutarate dehydrogenase antibody, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) antibody, OGDH antibody, Ogdh antibody

Background: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,OGDH,AKGDH,E1k,OGDC,Cancer,Signal Transduction,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,Lipid Metabolism,Hydrolysis,Cardiovascular,Lipids,OGDH

Molecular Weight: 48 kDa/115 kDa

Gene ID: 4967

UniProt: Q02218