NRARP antibody (AA 1-114)

Catalog No. ABIN6144838

Product Details anti-NRARP Antibody

Target: NRARP (NOTCH-Regulated Ankyrin Repeat Protein (NRARP))

Binding Specificity: AA 1-114

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NRARP antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: MSQAELSTCS APQTQRIFQE AVRKGNTQEL QSLLQNMTNC EFNVNSFGPE GQTALHQSVI DGNLELVKLL VKFGADIRLA NRDGWSALHI AAFGGHQDIV LYLITKAKYA ASGR

Cross-Reactivity: Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human NRARP (NP_001004354.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NRARP

Target: NRARP (NOTCH-Regulated Ankyrin Repeat Protein (NRARP))

Alternative Name: NRARP (NRARP Products)

Background: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity.,NRARP,Cell Biology & Developmental Biology,Neuroscience,Cardiovascular,Angiogenesis,NRARP

Molecular Weight: 12 kDa

Gene ID: 441478

UniProt: Q7Z6K4