NCOR2 antibody (AA 670-900)

Catalog No. ABIN6144422

Product Details anti-NCOR2 Antibody

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Binding Specificity: AA 670-900

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: KLKMEKERNA RRKKKKAPAA ASEEAAFPPV VEDEEMEASG VSGNEEEMVE EAEALHASGN EVPRGECSGP ATVNNSSDTE SIPSPHTEAA KDTGQNGPKP PATLGADGPP PGPPTPPPED IPAPTEPTPA SEATGAPTPP PAPPSPSAPP PVVPKEEKEE ETAAAPPVEE GEEQKPPAAE ELAVDTGKAE EPVKSECTEE AEEGPAKGKD AEAAEATAEG ALKAEKKEGG S

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 670-900 of human NCOR2 (NP_006303.4).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCOR2

Target: NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))

Alternative Name: NCOR2 (NCOR2 Products)

Synonyms: CTG26 antibody, N-CoR2 antibody, SMAP270 antibody, SMRT antibody, SMRTE antibody, SMRTE-tau antibody, TNRC14 antibody, TRAC antibody, TRAC-1 antibody, TRAC1 antibody, N-CoR antibody, SMRTe antibody, NCOR2 antibody, gb:be017685 antibody, si:bz71m17.2 antibody, smrt antibody, ctg26 antibody, smrte antibody, trac1 antibody, tnrc14 antibody, trac-1 antibody, smrte-tau antibody, nuclear receptor corepressor 2 antibody, nuclear receptor co-repressor 2 antibody, NCOR2 antibody, Ncor2 antibody, ncor2 antibody

Background: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.,NCOR2,CTG26,N-CoR2,SMAP270,SMRT,SMRTE,SMRTE-tau,TNRC14,TRAC,TRAC-1,TRAC1,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Notch Signaling Pathway,Endocrine & Metabolism,Lipid Metabolism,NCOR2

Molecular Weight: 81 kDa/268 kDa/273 kDa/274 kDa

Gene ID: 9612

UniProt: Q9Y618

Pathways: Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha