NCOA2 antibody (AA 550-820)

Catalog No. ABIN6144413

Product Details anti-NCOA2 Antibody

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Binding Specificity: AA 550-820

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: SSLASPDLKM GNLQNSPVNM NPPPLSKMGS LDSKDCFGLY GEPSEGTTGQ AESSCHPGEQ KETNDPNLPP AVSSERADGQ SRLHDSKGQT KLLQLLTTKS DQMEPSPLAS SLSDTNKDST GSLPGSGSTH GTSLKEKHKI LHRLLQDSSS PVDLAKLTAE ATGKDLSQES SSTAPGSEVT IKQEPVSPKK KENALLRYLL DKDDTKDIGL PEITPKLERL DSKTDPASNT KLIAMKTEKE EMSFEPGDQP GSELDNLEEI LDDLQNSQLP Q

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 550-820 of human NCOA2 (NP_006531.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NCOA2

Target: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Alternative Name: NCOA2 (NCOA2 Products)

Synonyms: GRIP1 antibody, KAT13C antibody, NCoA-2 antibody, SRC2 antibody, TIF2 antibody, bHLHe75 antibody, 9530095N19 antibody, D1Ertd433e antibody, GRIP-1 antibody, Grip1 antibody, SRC-2 antibody, TIF-2 antibody, tif2 antibody, wu:fc41a10 antibody, wu:fe26a11 antibody, Tif2 antibody, NCOA2 antibody, XTIF2 antibody, bhlhe75 antibody, grip1 antibody, kat13c antibody, src2 antibody, ncoa2-A antibody, nuclear receptor coactivator 2 antibody, nuclear receptor coactivator 2 S homeolog antibody, NCOA2 antibody, Ncoa2 antibody, ncoa2 antibody, LOC100089041 antibody, ncoa2.S antibody

Background: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants.,NCOA2,GRIP1,KAT13C,NCoA-2,SRC2,TIF2,bHLHe75,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Cancer,Endocrine & Metabolism,Lipid Metabolism,Endocrine and metabolic diseases,Obesity,NCOA2

Molecular Weight: 159 kDa

Gene ID: 10499

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling