MRPS12 antibody (AA 30-138)

Catalog No. ABIN6144024

Product Details anti-MRPS12 Antibody

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Binding Specificity: AA 30-138

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRPS12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: MATLNQMHRL GPPKRPPRKL GPTEGRPQLK GVVLCTFTRK PKKPNSANRK CCRVRLSTGR EAVCFIPGEG HTLQEHQIVL VEGGRTQDLP GVKLTVVRGK YDCGHVQKK

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-138 of human MRPS12 (NP_203527.1).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MRPS12

Target: MRPS12 (Mitochondrial Ribosomal Protein S12 (MRPS12))

Alternative Name: MRPS12 (MRPS12 Products)

Background: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75 % protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene, all three variants encode the same protein.,MRPS12,MPR-S12,MT-RPS12,RPMS12,RPS12,RPSM12,Epigenetics & Nuclear Signaling,MRPS12

Molecular Weight: 15 kDa

Gene ID: 6183

UniProt: O15235

Pathways: Sensory Perception of Sound