MRGPRX1 antibody (AA 263-322)

Catalog No. ABIN6143996

Product Details anti-MRGPRX1 Antibody

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Binding Specificity: AA 263-322

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX1 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LNSSANPIIY FFVGSFRQRQ NRQNLKLVLQ RALQDASEVD EGGGQLPEEI LELSGSRLEQ

Cross-Reactivity: Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 263-322 of human MRGPRX1 (NP_671732.3).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MRGPRX1

Target: MRGPRX1 (MAS-Related GPR, Member X1 (MRGPRX1))

Alternative Name: MRGPRX1 (MRGPRX1 Products)

Background: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22 and BAM (8-22(PubMed:26582731. BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alphaq proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.,MRGPRX1,GPCR,MGRG2,MRGX1,SNSR4,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),MRGPRX1

Molecular Weight: 36 kDa

Gene ID: 259249

UniProt: Q96LB2