MME antibody (AA 52-352)

Catalog No. ABIN6143900

Product Details anti-MME Antibody

Target: MME (Membrane Metallo-Endopeptidase (MME))

Binding Specificity: AA 52-352

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MME antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: YDDGICKSSD CIKSAARLIQ NMDATTEPCT DFFKYACGGW LKRNVIPETS SRYGNFDILR DELEVVLKDV LQEPKTEDIV AVQKAKALYR SCINESAIDS RGGEPLLKLL PDIYGWPVAT ENWEQKYGAS WTAEKAIAQL NSKYGKKVLI NLFVGTDDKN SVNHVIHIDQ PRLGLPSRDY YECTGIYKEA CTAYVDFMIS VARLIRQEER LPIDENQLAL EMNKVMELEK EIANATAKPE DRNDPMLLYN KMTLAQIQNN FSLEINGKPF SWLNFTNEIM STVNISITNE EDVVVYAPEY L

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 52-352 of human CD10/CD10/MME (NP_009220.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-MME antibody (ABIN6143900)

Wu, Kong, Wang, Chen, Wang: "Spatiotemporal expression of endogenous opioid processing enzymes in mouse uterus at peri-implantation." in: Cell and tissue research, Vol. 363, Issue 2, pp. 555-65, (2016) (PubMed).

Target Details for MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Alternative Name: MME (MME Products)

Synonyms: CALLA antibody, CD10 antibody, NEP antibody, SFE antibody, 6030454K05Rik antibody, C85356 antibody, Nep antibody, neprilysin antibody, membrane metalloendopeptidase antibody, membrane metallo endopeptidase antibody, membrane metallo-endopeptidase antibody, MME antibody, Mme antibody

Background: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85 % of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.,CALLA,CD10,CMT2T,NEP,SCA43,SFE,MME,Cancer,Tumor immunology,Immunology & Inflammation,CD markers,Neuroscience,Neurodegenerative Diseases,Stem Cells,Hematopoietic Progenitors,Mesenchymal Stem Cells,MME

Molecular Weight: 85 kDa

Gene ID: 4311

UniProt: P08473

Pathways: RTK Signaling, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration