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MLKL antibody (C-Term)

MLKL Reactivity: Mouse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6143882
  • Target See all MLKL Antibodies
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Binding Specificity
    • 11
    • 11
    • 9
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 56
    • 39
    • 17
    • 1
    • 1
    Mouse
    Host
    • 67
    • 7
    Rabbit
    Clonality
    • 60
    • 14
    Polyclonal
    Conjugate
    • 32
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    This MLKL antibody is un-conjugated
    Application
    • 32
    • 29
    • 13
    • 11
    • 6
    • 5
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    EGCDSKKIRE LVAEDKKQEP VGQDCPELLR EIINECRAHE PSQRPSVDGR SLSGRERILE RLSAVEESTD KKV
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    A synthetic peptide corresponding to a sequence within amino acids 400 to the C-terminus of mouse MLKL (NP_001297542.1).
    Isotype
    IgG
    Top Product
    Discover our top product MLKL Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Alternative Name
    MLKL (MLKL Products)
    Synonyms
    MLKL antibody, 9130019I15Rik antibody, mixed lineage kinase domain like pseudokinase antibody, mixed lineage kinase domain-like antibody, MLKL antibody, mlkl antibody, Mlkl antibody
    Background
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.,MLKL,hMLKL,Signal Transduction,Kinase,MLKL
    Molecular Weight
    53 kDa/54 kDa
    Gene ID
    74568
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