MLH3 antibody (AA 1180-1429)

Catalog No. ABIN6143878

Product Details anti-MLH3 Antibody

Target: MLH3 (MutL Homolog 3 (MLH3))

Binding Specificity: AA 1180-1429

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MLH3 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RFTKGMIHSM QVLQQVDNKF IACLMSTKTE ENGEADSYEK QQAQGSGRKK LLSSTLIPPL EITVTEEQRR LLWCYHKNLE DLGLEFVFPD TSDSLVLVGK VPLCFVEREA NELRRGRSTV TKSIVEEFIR EQLELLQTTG GIQGTLPLTV QKVLASQACH GAIKFNDGLS LQESCRLIEA LSSCQLPFQC AHGRPSMLPL ADIDHLEQEK QIKPNLTKLR KMAQAWRLFG KAECDTRQSL QQSMPPCEPP

Cross-Reactivity: Human

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1180-1429 of human MLH3 (NP_055196.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MLH3

Target: MLH3 (MutL Homolog 3 (MLH3))

Alternative Name: MLH3 (MLH3 Products)

Synonyms: AV125803 antibody, BB126472 antibody, MGC80774 antibody, MLH3 antibody, HNPCC7 antibody, mutL homolog 3 antibody, mutL homolog 3 L homeolog antibody, Mlh3 antibody, mlh3.L antibody, MLH3 antibody, mlh3 antibody

Background: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.,MLH3,HNPCC7,Epigenetics & Nuclear Signaling,DNA Damage & Repair,MLH3

Molecular Weight: 161 kDa/163 kDa

Gene ID: 27030

UniProt: Q9UHC1

Pathways: Chromatin Binding