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MELK antibody (AA 412-651)

MELK Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6143725
  • Target See all MELK Antibodies
    MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
    Binding Specificity
    • 15
    • 8
    • 8
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 412-651
    Reactivity
    • 61
    • 18
    • 14
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    Human
    Host
    • 60
    • 5
    • 1
    Rabbit
    Clonality
    • 60
    • 6
    Polyclonal
    Conjugate
    • 35
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MELK antibody is un-conjugated
    Application
    • 38
    • 29
    • 13
    • 13
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    LCRTPANKLK NKENVYTPKS AVKNEEYFMF PEPKTPVNKN QHKREILTTP NRYTTPSKAR NQCLKETPIK IPVNSTGTDK LMTGVISPER RCRSVELDLN QAHMEETPKR KGAKVFGSLE RGLDKVITVL TRSKRKGSAR DGPRRLKLHY NVTTTRLVNP DQLLNEIMSI LPKKHVDFVQ KGYTLKCQTQ SDFGKVTMQF ELEVCQLQKP DVVGIRRQRL KGDAWVYKRL VEDILSSCKV
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 412-651 of human MELK (NP_055606.1).
    Isotype
    IgG
    Top Product
    Discover our top product MELK Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:100 - 1:200
    Comment

    HIGH QUALITY

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MELK (Maternal Embryonic Leucine Zipper Kinase (MELK))
    Alternative Name
    MELK (MELK Products)
    Synonyms
    MELK antibody, xmelk antibody, Melk antibody, HPK38 antibody, AI327312 antibody, MPK38 antibody, mKIAA0175 antibody, fb71b01 antibody, fe01f04 antibody, wu:fb71b01 antibody, wu:fe01f04 antibody, maternal embryonic leucine zipper kinase antibody, maternal embryonic leucine zipper kinase L homeolog antibody, MELK antibody, melk antibody, cgd5_2270 antibody, Melk antibody, melk.L antibody
    Background
    Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity, phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.,MELK,HPK38,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Stem Cells,Embryonic Stem Cells,MELK
    Molecular Weight
    52 kDa/59 kDa/66 kDa/69 kDa/70 kDa/71 kDa/74 kDa
    Gene ID
    9833
    UniProt
    Q14680
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