MCM10 antibody (AA 616-875)
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- Target See all MCM10 Antibodies
- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
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Binding Specificity
- AA 616-875
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MCM10 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- RLEGAPATMT PKLGRGVLEG DDVLFYDESP PPRPKLSALA EAKKLAAITK LRAKGQVLTK TNPNSIKKKQ KDPQDILEVK ERVEKNTMFS SQAEDELEPA RKKRREQLAY LESEEFQKIL KAKSKHTGIL KEAEAEMQER YFEPLVKKEQ MEEKMRNIRE VKCRVVTCKT CAYTHFKLLE TCVSEQHEYH WHDGVKRFFK CPCGNRSISL DRLPNKHCSN CGLYKWERDG MLKEKTGPKI GGETLLPRGE EHAKFLNSLK
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 616-875 of human MCM10 (NP_877428.1).
- Isotype
- IgG
- Top Product
- Discover our top product MCM10 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
- Alternative Name
- MCM10 (MCM10 Products)
- Synonyms
- CG9241 antibody, DmMCM10 antibody, Dmel\\CG9241 antibody, Scim19 antibody, mcm10 antibody, CNA43 antibody, DNA43 antibody, xmcm10 antibody, 2410041F14Rik antibody, AU018508 antibody, C330019M07Rik antibody, C79164 antibody, Minichromosome maintenance 10 antibody, minichromosome maintenance 10 replication initiation factor antibody, minichromosome maintenance 10 replication initiation factor L homeolog antibody, Mcm10 antibody, MCM10 antibody, mcm10.L antibody
- Background
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.,MCM10,CNA43,DNA43,PRO2249,Epigenetics & Nuclear Signaling,MCM10
- Molecular Weight
- 98 kDa
- Gene ID
- 55388
- UniProt
- Q7L590
- Pathways
- Mitotic G1-G1/S Phases, DNA Replication
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