MCFD2 antibody (AA 27-146)

Catalog No. ABIN6143636

Product Details anti-MCFD2 Antibody

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Binding Specificity: AA 27-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCFD2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Sequence: EEPAASFSQP GSMGLDKNTV HDQEHIMEHL EGVINKPEAE MSPQELQLHY FKMHDYDGNN LLDGLELSTA ITHVHKEEGS EQAPLMSEDE LINIIDGVLR DDDKNNDGYI DYAEFAKSLQ

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 27-146 of human MCFD2 (NP_644808.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:100 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MCFD2

Target: MCFD2 (Multiple Coagulation Factor Deficiency 2 (MCFD2))

Alternative Name: MCFD2 (MCFD2 Products)

Synonyms: hm:zeh1186 antibody, wu:fc23b10 antibody, wu:fd50d08 antibody, zgc:103713 antibody, zgc:109915 antibody, MCFD2 antibody, DKFZp469B098 antibody, F5F8D antibody, F5F8D2 antibody, LMAN1IP antibody, SDNSF antibody, 1810021C21Rik antibody, F5f8d antibody, Lman1ip antibody, Sdnsf antibody, multiple coagulation factor deficiency 2 antibody, multiple coagulation factor deficiency 2 L homeolog antibody, MCFD2 antibody, mcfd2 antibody, mcfd2.L antibody, Mcfd2 antibody

Background: This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LMAN1 (lectin mannose binding protein 1, also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D), a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,MCFD2,F5F8D,F5F8D2,LMAN1IP,SDNSF,Signal Transduction,MCFD2

Molecular Weight: 10 kDa/14 kDa/16 kDa

Gene ID: 90411

UniProt: Q8NI22