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MC1 Receptor antibody (AA 1-80)

MC1R Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6143610
  • Target See all MC1 Receptor (MC1R) Antibodies
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Binding Specificity
    • 16
    • 15
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-80
    Reactivity
    • 63
    • 27
    • 11
    • 4
    • 3
    • 1
    • 1
    Human
    Host
    • 65
    • 10
    Rabbit
    Clonality
    • 72
    • 3
    Polyclonal
    Conjugate
    • 28
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MC1 Receptor antibody is un-conjugated
    Application
    • 51
    • 27
    • 26
    • 26
    • 14
    • 12
    • 8
    • 8
    • 6
    • 4
    • 2
    Western Blotting (WB)
    Sequence
    MAVQGSQRRL LGSLNSTPTA IPQLGLAANQ TGARCLEVSI SDGLFLSLGL VSLVENALVV ATIAKNRNLH SPMYCFICCL
    Cross-Reactivity
    Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human MC1 Receptor (NP_002377.4).
    Isotype
    IgG
    Top Product
    Discover our top product MC1R Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))
    Alternative Name
    MC1R (MC1R Products)
    Synonyms
    CMM5 antibody, MSH-R antibody, SHEP2 antibody, Mshra antibody, Tob antibody, e antibody, MC1-R antibody, MSHR antibody, mc1r antibody, MC1R antibody, TUBB3 antibody, melanocortin 1 receptor antibody, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antibody, MC1R antibody, Mc1r antibody, mc1r antibody, mc1r_par1 antibody
    Background
    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.,MC1R,CMM5,MSH-R,SHEP2,Signal Transduction,G protein signaling,G-Protein-Coupled Receptors(GPCR),Endocrine & Metabolism,Neuroscience,MC1R
    Molecular Weight
    34 kDa
    Gene ID
    4157
    UniProt
    Q01726
    Pathways
    cAMP Metabolic Process, Feeding Behaviour
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