AW107687 antibody, LAMAN antibody, Laman antibody, Manb antibody, MANB antibody, mannosidase alpha class 2B member 1 antibody, mannosidase, alpha, class 2B, member 1 antibody, mannosidase 2, alpha B1 antibody, MAN2B1 antibody, man2b1 antibody, Man2b1 antibody
Background
This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,MAN2B1,LAMAN,MANB,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,MAN2B1