LIG3 antibody (AA 730-1009)

Catalog No. ABIN6143207

Product Details anti-LIG3 Antibody

Target: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Binding Specificity: AA 730-1009

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIG3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: AGGHDDATLA RLQNELDMVK ISKDPSKIPS WLKVNKIYYP DFIVPDPKKA AVWEITGAEF SKSEAHTADG ISIRFPRCTR IRDDKDWKSA TNLPQLKELY QLSKEKADFT VVAGDEGSST TGGSSEENKG PSGSAVSRKA PSKPSASTKK AEGKLSNSNS KDGNMQTAKP SAMKVGEKLA TKSSPVKVGE KRKAADETLC QTKVLLDIFT GVRLYLPPST PDFSRLRRYF VAFDGDLVQE FDMTSATHVL GSRDKNPAAQ QVSPEWIWAC IRKRRLVAPC

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 730-1009 of human LIG3 (NP_039269.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for LIG3

Target: LIG3 (Ligase III, DNA, ATP-Dependent (LIG3))

Alternative Name: LIG3 (LIG3 Products)

Background: This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.,LIG3,LIG2,Epigenetics & Nuclear Signaling,LIG3

Molecular Weight: 95 kDa/102 kDa/106 kDa/112 kDa

Gene ID: 3980

UniProt: P49916

Pathways: DNA Damage Repair