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LAMB2 antibody (AA 1579-1798)

LAMB2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6143070
  • Target See all LAMB2 Antibodies
    LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))
    Binding Specificity
    • 15
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1579-1798
    Reactivity
    • 49
    • 18
    • 16
    Human
    Host
    • 55
    • 2
    Rabbit
    Clonality
    • 55
    • 2
    Polyclonal
    Conjugate
    • 23
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LAMB2 antibody is un-conjugated
    Application
    • 31
    • 22
    • 21
    • 13
    • 13
    • 7
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequence
    DVRRAEQLLQ DARRARSWAE DEKQKAETVQ AALEEAQRAQ GIAQGAIRGA VADTRDTEQT LYQVQERMAG AERALSSAGE RARQLDALLE ALKLKRAGNS LAASTAEETA GSAQGRAQEA EQLLRGPLGD QYQTVKALAE RKAQGVLAAQ ARAEQLRDEA RDLLQAAQDK LQRLQELEGT YEENERALES KAAQLDGLEA RMRSVLQAIN LQVQIYNTCQ
    Cross-Reactivity
    Human, Mouse
    Characteristics
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 1579-1798 of human LAMB2 (NP_002283.3).
    Isotype
    IgG
    Top Product
    Discover our top product LAMB2 Primary Antibody
  • Application Notes
    WB,1:1000 - 1:2000,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    LAMB2 (Laminin, beta 2 (Laminin S) (LAMB2))
    Alternative Name
    LAMB2 (LAMB2 Products)
    Synonyms
    LAMS antibody, NPHS5 antibody, AW211941 antibody, Lamb-2 antibody, Lams antibody, SLAM antibody, lamb1 antibody, lams antibody, LAMC1 antibody, laminin antibody, laminin subunit beta 2 antibody, laminin, beta 2 antibody, laminin subunit beta 2 L homeolog antibody, laminin, beta 2 (laminin S) antibody, LAMB2 antibody, Lamb2 antibody, lamb2.L antibody
    Background
    Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma . Some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form.,LAMB2,LAMS,NPHS5,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Intermediate Filaments,Extracellular Matrix,Neuroscience,Cardiovascular,Angiogenesis,LAMB2
    Molecular Weight
    195 kDa
    Gene ID
    3913
    UniProt
    P55268
    Pathways
    Skeletal Muscle Fiber Development
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