Laminin beta 1 antibody (AA 1467-1786)

Catalog No. ABIN6143068

Product Details anti-Laminin beta 1 Antibody

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Binding Specificity: AA 1467-1786

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Laminin beta 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Sequence: EAKLRADEAK QSAEDILLKT NATKEKMDKS NEELRNLIKQ IRNFLTQDSA DLDSIEAVAN EVLKMEMPST PQQLQNLTED IRERVESLSQ VEVILQHSAA DIARAEMLLE EAKRASKSAT DVKVTADMVK EALEEAEKAQ VAAEKAIKQA DEDIQGTQNL LTSIESETAA SEETLFNASQ RISELERNVE ELKRKAAQNS GEAEYIEKVV YTVKQSAEDV KKTLDGELDE KYKKVENLIA KKTEESADAR RKAEMLQNEA KTLLAQANSK LQLLKDLERK YEDNQRYLED KAQELARLEG EVRSLLKDIS QKVAVYSTCL

Cross-Reactivity: Human, Mouse

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1467-1786 of human Laminin beta 1 (NP_002282.2).

Isotype: IgG

Application Details

Application Notes: WB,1:1000 - 1:4000,IF,1:50 - 1:200

Comment:

HIGH QUALITY

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Laminin beta 1

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Alternative Name: LAMB1 (LAMB1 Products)

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.,LAMB1,CLM,LIS5,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,Cardiovascular,Angiogenesis,LAMB1

Molecular Weight: 198 kDa

Gene ID: 3912

UniProt: P07942