KLHL3 antibody (AA 1-110)
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- Target See all KLHL3 Antibodies
- KLHL3 (Kelch-Like 3 (KLHL3))
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Binding Specificity
- AA 1-110
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This KLHL3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MEGESVKLSS QTLIQAGDDE KNQRTITVNP AHMGKAFKVM NELRSKQLLC DVMIVAEDVE IEAHRVVLAA CSPYFCAMFT GDMSESKAKK IEIKDVDGQT LSKLIDYIYT
- Cross-Reactivity
- Human, Mouse
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human KLHL3 (NP_059111.2).
- Isotype
- IgG
- Top Product
- Discover our top product KLHL3 Primary Antibody
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- Application Notes
- WB,1:500 - 1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- KLHL3 (Kelch-Like 3 (KLHL3))
- Alternative Name
- KLHL3 (KLHL3 Products)
- Synonyms
- 7530408C15Rik antibody, AI430941 antibody, EG627648 antibody, PHA2D antibody, RGD1565218 antibody, kelch like family member 3 antibody, kelch-like 3 antibody, kelch-like family member 3 antibody, KLHL3 antibody, Klhl3 antibody
- Background
- This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D), a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.,KLHL3,PHA2D,Cell Biology & Developmental Biology,KLHL3
- Molecular Weight
- 55 kDa/61 kDa/64 kDa
- Gene ID
- 26249
- UniProt
- Q9UH77
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