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IREB2 antibody (AA 1-250)
IREB2
Reactivity: Human
WB, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IREB2 Antibody
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Target
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IREB2
(Iron-Responsive Element Binding Protein 2 (IREB2))
Binding Specificity
All epitopes for IREB2 antibodies
AA 1-250
Reactivity
All reactivities for IREB2 antibodies
Human
Host
All hosts for IREB2 antibodies
Rabbit
Clonality
All clonalities for IREB2 antibodies
Polyclonal
Conjugate
All conjugates for IREB2 antibodies
This IREB2 antibody is un-conjugated
Application
All applications for IREB2 antibodies
Western Blotting (WB), Immunofluorescence (IF)
Sequence
MDAPKAGYAF EYLIETLNDS SHKKFFDVSK LGTKYDVLPY SIRVLLEAAV RNCDGFLMKK EDVMNILDWK TKQSNVEVPF FPARVLLQDF TGIPAMVDFA AMREAVKTLG GDPEKVHPAC PTDLTVDHSL QIDFSKCAIQ NAPNPGGGDL QKAGKLSPLK VQPKKLPCRG QTTCRGSCDS GELGRNSGTF SSQIENTPIL CPFHLQPVPE PETVLKNQEV EFGRNRERLQ FFKWSSRVFK NVAVIPPGTG
Cross-Reactivity
Human, Mouse, Rat
Characteristics
Polyclonal Antibodies
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human IREB2 (NP_004127.1).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
WB,1:500 - 1:2000,IF,1:20 - 1:50
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for IREB2
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Target
IREB2
(Iron-Responsive Element Binding Protein 2 (IREB2))
Alternative Name
IREB2 (IREB2 Products )
Background
RNA-binding protein that binds to iron-responsive elements (IRES, which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.,IREB2,ACO3,IRP2,IRP2AD,Endocrine & Metabolism,Cardiovascular,Hypoxia,Hypoxia-Regulated,IREB2
Molecular Weight
37 kDa/105 kDa
Gene ID
3658
UniProt
P48200
Pathways
Transition Metal Ion Homeostasis
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